Male Sphynx cat experiences gender transition by accident!


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A veterinarian in Prague recently saw something abnormal in one of his patients. The owner had brought his beloved male Sphynx cat for an examination due to enlarged mammary glands. Terrified of why this was happening to her one-year-old male cat, she reported that they had swelled in just 2 days.

For the staff at the Prague Veterinary Clinic in the Czech Republic, the diagnosis was not easy.

At first, they checked to see if the swelling was due to tumors. No, the samples of the pieces themselves did not show any cancer cells.

Then they performed an ultrasound on the poor sphynx boy. It was possible that a tumor had formed on his adrenal gland, which would affect his hormones.

“As part of your endocrine system, the adrenal glands produce hormones. They give instructions to virtually every organ and tissue in your body ”, explains

The results of these tests were also negative. They ruled out the possibility that he had tumors in his testicles. They checked for anything that could be related to the mammary glands. Covering all the bases, they confirmed that the cat was not an hermaphrodite either. This happens when one has both male and female reproductive organs.

There was no response and they were forced to wait for the return of the blood test results.

When the veterinarian MVDr. Martina Načeradská received the results, she was shocked by what they showed.

“The lab confirmed an extreme increase in estrogen levels, so high that they were afraid to communicate it,” she admitted to “They were convinced it was a measurement error.”

MVDr. Martina Načeradská

Apparently, the male’s estrogen levels were higher than those of a cat… in heat!

They discussed with the frightened woman what could have caused this reaction. One theory they focused on was the medications in the house that the cat could have gotten into.

Even though she knew the cat hadn’t eaten any pills, what they eventually discovered was just as dangerous.

In the 4 months leading up to the show, the woman had undergone a gender transformation. (Seems pretty obvious, in my opinion they should have linked the two faster.) The process includes many prescriptions related to hormones. One of them was Lenzetto, used in hormone replacement therapy (HRT).

According to Lenzetto leaflet insert, “It contains a female hormone, from the estrogen group. Lenzetto is used in postmenopausal women who are at least 6 months since their last natural period. [It] can also be used in women who have had surgery to remove their ovaries because it causes instant menopause.

Lenzetto is a spray solution that contains small amounts of a medicine called estradiol. When sprayed on the skin as directed, it passes through the skin into your bloodstream.

Unfortunately, after using the spray, the woman did not wash her hands before snuggling up to her beloved cat.

It is even worse when the application site is inside the forearm… a favorite cat spot. Now imagine what it does to a 10 pound cat without fur to reduce exposure. The vet believes the coincidence that it was a sphynx cat made the worst case possible. It was as if the cat joined its master during the gender transformation.

Fortunately, as rare as it is to discover, the solution was simple. Wash after use and keep the cat away from the application site.

Eventually the swelling subsided and the lucky feline returned to normal – with a relieved mom!


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